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Multiple Choice

Which syndrome is associated with tall stature and an extra Y chromosome in males?

An extra Y chromosome in a male leads to XYY syndrome, which is typically associated with tall stature. This condition usually arises from nondisjunction during spermatogenesis, producing a 47,XYY karyotype. Most individuals have normal sexual development and fertility, but some may have learning difficulties, speech delays, or behavioral challenges. Turner syndrome is a female condition (monosomy X), Klinefelter syndrome is XXY in males, and Lesch-Nyhan is a metabolic disorder, not a sex-chromosome–related condition. So the tall stature with an extra Y chromosome specifically points to XYY syndrome.

An extra Y chromosome in a male leads to XYY syndrome, which is typically associated with tall stature. This condition usually arises from nondisjunction during spermatogenesis, producing a 47,XYY karyotype. Most individuals have normal sexual development and fertility, but some may have learning difficulties, speech delays, or behavioral challenges. Turner syndrome is a female condition (monosomy X), Klinefelter syndrome is XXY in males, and Lesch-Nyhan is a metabolic disorder, not a sex-chromosome–related condition. So the tall stature with an extra Y chromosome specifically points to XYY syndrome.