Which neurotransmitter is primarily used by the globus pallidus as its inhibitory output?

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The main idea is that the globus pallidus acts as an inhibitory output node, and its primary neurotransmitter for that output is GABA. In the basal ganglia circuitry, the internal segment of the globus pallidus (GPi) sends GABAergic projections to the thalamus, supplying tonic inhibition that modulates thalamocortical drive and movement. This GABA-mediated inhibition is what shapes motor signals before they reach the cortex. Dopamine from the substantia nigra modulates striatal activity rather than serving as the main inhibitory output from the globus pallidus itself; glutamate is the main excitatory transmitter used by afferents like the cortex and subthalamic nucleus; acetylcholine has important roles within the striatum, but not as the primary inhibitory output from the globus pallidus.