Which medication is used to treat hyperuricemia in Lesch-Nyhan syndrome?

Prepare for the American Board of Professional Psychology (ABPP) Exam with flashcards and multiple-choice questions. Each question includes insights and explanations to help you excel. Get ready for your certification journey!

Multiple Choice

Which medication is used to treat hyperuricemia in Lesch-Nyhan syndrome?

Explanation:
Lesch-Nyhan syndrome causes overproduction of uric acid due to HGPRT deficiency, so reducing uric acid production is a key management goal. Allopurinol inhibits xanthine oxidase, the enzyme that converts hypoxanthine and xanthine into uric acid, thereby lowering uric acid levels. This helps prevent urate crystal deposition, gout, and kidney stones seen in this condition. The other medications listed do not address uric acid production: diphenhydramine is an antihistamine, risperidone is an antipsychotic, and selegiline is an MAO-B inhibitor for Parkinson’s disease.

Lesch-Nyhan syndrome causes overproduction of uric acid due to HGPRT deficiency, so reducing uric acid production is a key management goal. Allopurinol inhibits xanthine oxidase, the enzyme that converts hypoxanthine and xanthine into uric acid, thereby lowering uric acid levels. This helps prevent urate crystal deposition, gout, and kidney stones seen in this condition. The other medications listed do not address uric acid production: diphenhydramine is an antihistamine, risperidone is an antipsychotic, and selegiline is an MAO-B inhibitor for Parkinson’s disease.

More practice questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy