Which lesion location is associated with alexia with agraphia?

• A. Left posterior corpus callosum, inferior temporal gyrus
• B. Verbal apraxia in childhood
• C. Left frontal lobe precentral gyrus
• D. Left temporo-parietal angular gyrus

Answer: (C)

Reading and writing rely on the left temporoparietal junction, especially the angular gyrus, which serves as the interface between visual word forms and language processing. When this dominant-hemisphere region is damaged, the ability to read (alexia) and to spell/write (agraphia) is disrupted because the mappings between letters, sounds, and language representations can no longer be integrated. This location is the classic site for alexia with agraphia.

A lesion in the left frontal precentral gyrus would primarily affect motor execution and planning for speech, not the core reading and writing pathways. Verbal apraxia in childhood is a speech-motor planning issue rather than a reading/writing disorder. A lesion in the left posterior corpus callosum with inferior temporal gyrus would involve interhemispheric transfer or other visual processing aspects, but the hallmark pattern of alexia with agraphia most classically points to the left temporo-parietal angular gyrus.