Which genetic disorder is associated with severe intellectual disability relative to the others?

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Multiple Choice

Which genetic disorder is associated with severe intellectual disability relative to the others?

Explanation:
Angelman syndrome is the one most strongly associated with severe intellectual disability among these conditions. It results from loss of expression of the maternal UBE3A gene on chromosome 15, which in the brain leads to profound developmental delay and cognitive impairment, often with minimal or no speech, ataxia, and seizures. In contrast, Prader-Willi typically shows intellectual disability as well but usually not as severe and is accompanied by hypotonia and hyperphagia; Fragile X features intellectual disability with variable severity (often more pronounced in males) and a distinct facial/story; Williams syndrome involves mild-to-moderate intellectual disability with relatively strong language and social skills. So the unusually deep cognitive impairment characterizes Angelman most clearly.

Angelman syndrome is the one most strongly associated with severe intellectual disability among these conditions. It results from loss of expression of the maternal UBE3A gene on chromosome 15, which in the brain leads to profound developmental delay and cognitive impairment, often with minimal or no speech, ataxia, and seizures. In contrast, Prader-Willi typically shows intellectual disability as well but usually not as severe and is accompanied by hypotonia and hyperphagia; Fragile X features intellectual disability with variable severity (often more pronounced in males) and a distinct facial/story; Williams syndrome involves mild-to-moderate intellectual disability with relatively strong language and social skills. So the unusually deep cognitive impairment characterizes Angelman most clearly.

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