Which disorder is associated with tau pathology and frontoparietal and substantia nigra involvement, often with asymmetric onset and poor response to levodopa?

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Multiple Choice

Which disorder is associated with tau pathology and frontoparietal and substantia nigra involvement, often with asymmetric onset and poor response to levodopa?

Tau-driven cortical and nigral degeneration with asymmetric onset and poor response to levodopa points to corticobasal degeneration. This tauopathy features accumulations of 4R tau spreading in the frontoparietal cortex and substantia nigra, producing cortical signs such as apraxia and sensory disturbances alongside asymmetric parkinsonism. The limited benefit from levodopa reflects the cortical pathology driving the syndrome, not just nigrostriatal dopamine loss. Huntington disease centers on caudate degeneration and chorea from a genetic CAG expansion, not a tauopathy; MSA is a synucleinopathy with autonomic and cerebellar features and different pathology; HIV-associated neurocognitive disorder stems from HIV-related CNS injury. Thus the described pattern aligns with corticobasal degeneration.

Tau-driven cortical and nigral degeneration with asymmetric onset and poor response to levodopa points to corticobasal degeneration. This tauopathy features accumulations of 4R tau spreading in the frontoparietal cortex and substantia nigra, producing cortical signs such as apraxia and sensory disturbances alongside asymmetric parkinsonism. The limited benefit from levodopa reflects the cortical pathology driving the syndrome, not just nigrostriatal dopamine loss. Huntington disease centers on caudate degeneration and chorea from a genetic CAG expansion, not a tauopathy; MSA is a synucleinopathy with autonomic and cerebellar features and different pathology; HIV-associated neurocognitive disorder stems from HIV-related CNS injury. Thus the described pattern aligns with corticobasal degeneration.

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