Which condition is most classically associated with frontotemporal dementia?

• A. Alzheimer's disease
• B. Lewy Body disease
• C. Pick's disease
• D. Huntington's disease

Answer: (C)

Frontotemporal dementia shows early behavioral and language changes due to degeneration of the frontal and anterior temporal lobes. The classic neuropathologic counterpart of this syndrome is Pick’s disease, historically described with Pick bodies (tau-containing inclusions) in neurons. This makes Pick’s disease the best match for frontotemporal dementia.

Alzheimer’s disease is typically dominated by memory impairment with temporoparietal atrophy; Lewy body disease features fluctuating cognition with visual hallucinations and parkinsonism; Huntington’s disease presents with chorea and caudate atrophy due to a genetic mutation.