Wernicke-Korsakoff syndrome is associated with deficiency of which vitamin?

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Multiple Choice

Wernicke-Korsakoff syndrome is associated with deficiency of which vitamin?

Thiamine (vitamin B1) deficiency underlies Wernicke-Korsakoff syndrome. Thiamine is a crucial cofactor for enzymes that convert glucose into energy in the brain. When stores are depleted, brain energy production falters, especially in vulnerable regions like the mammillary bodies and thalamus, leading to Wernicke’s encephalopathy symptoms (eye movement problems, ataxia, confusion) and, if not treated, the chronic memory problems and confabulation of Korsakoff syndrome. This condition is classically seen with chronic alcohol use, malnutrition, or malabsorption. Niacin deficiency causes pellagra; vitamin C deficiency causes scurvy; vitamin D deficiency causes bone problems.

Thiamine (vitamin B1) deficiency underlies Wernicke-Korsakoff syndrome. Thiamine is a crucial cofactor for enzymes that convert glucose into energy in the brain. When stores are depleted, brain energy production falters, especially in vulnerable regions like the mammillary bodies and thalamus, leading to Wernicke’s encephalopathy symptoms (eye movement problems, ataxia, confusion) and, if not treated, the chronic memory problems and confabulation of Korsakoff syndrome. This condition is classically seen with chronic alcohol use, malnutrition, or malabsorption. Niacin deficiency causes pellagra; vitamin C deficiency causes scurvy; vitamin D deficiency causes bone problems.

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