Velocardiofacial syndrome is inherited in which pattern and linked to which chromosome?

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Multiple Choice

Velocardiofacial syndrome is inherited in which pattern and linked to which chromosome?

Velocardiofacial syndrome arises from a microdeletion on the long arm of chromosome 22 at the 22q11.2 region. Losing one copy of this region is enough to produce the spectrum of features, so the inheritance pattern is autosomal dominant. Most cases occur as new deletions, but when a parent carries the deletion it can be transmitted in one generation with variable expression. This condition is not X-linked and is not on chromosomes 7 or 11, making chromosome 22 the correct locus.

Velocardiofacial syndrome arises from a microdeletion on the long arm of chromosome 22 at the 22q11.2 region. Losing one copy of this region is enough to produce the spectrum of features, so the inheritance pattern is autosomal dominant. Most cases occur as new deletions, but when a parent carries the deletion it can be transmitted in one generation with variable expression. This condition is not X-linked and is not on chromosomes 7 or 11, making chromosome 22 the correct locus.

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