Intrathecal methotrexate is a form of chemotherapy that can affect cognition. This therapy is best described as which category?

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Some chemotherapy agents can produce cognitive changes, especially when given directly into the central nervous system. Intrathecal methotrexate increases exposure of the brain to the drug, so it can cause cognitive toxicity, which is often discussed as chemo brain or chemotherapy-related cognitive impairment. Describing this therapy as chemotherapy that affects cognition captures the overall neurocognitive impact rather than labeling a specific symptom. Seizures, hearing loss, and mood swings are individual adverse events, not the general category for therapies with cognitive effects.