Intrathecal administration of methotrexate is delivered into which anatomical space?

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Multiple Choice

Intrathecal administration of methotrexate is delivered into which anatomical space?

Intrathecal administration targets the cerebrospinal fluid–filled space within the meninges. The subarachnoid space, located between the arachnoid and pia mater, contains CSF and is the conduit through which intrathecally delivered drugs like methotrexate circulate to reach malignant cells in the CNS. The epidural space lies outside the dura mater, the subdural space lies between the dura and arachnoid and does not house CSF, and the intracerebral space refers to the brain tissue itself, not a CSF compartment. Thus, methotrexate given intrathecally is delivered into the subarachnoid space.

Intrathecal administration targets the cerebrospinal fluid–filled space within the meninges. The subarachnoid space, located between the arachnoid and pia mater, contains CSF and is the conduit through which intrathecally delivered drugs like methotrexate circulate to reach malignant cells in the CNS. The epidural space lies outside the dura mater, the subdural space lies between the dura and arachnoid and does not house CSF, and the intracerebral space refers to the brain tissue itself, not a CSF compartment. Thus, methotrexate given intrathecally is delivered into the subarachnoid space.

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