In Pick's disease, which cognitive domains are typically spared?

• A. Memory and Visuospatial ability
• B. Memory
• C. Visuospatial ability
• D. Psychomotor ability

Answer: (A)

In Pick’s disease the brain shows early degeneration in the frontal and anterior temporal regions, which drives prominent behavioral changes and language problems. Because these regions are not the main hubs for storing new memories or for performing visuospatial tasks, those abilities tend to remain relatively intact in the early stages. Episodic memory and visuospatial processing rely more on other brain networks (medial temporal for memory and parietal/posterior regions for visuospatial skills), which is why they are spared early on. This pattern—early disruption of language and executive/behavioral functions with preserved memory and visuospatial abilities—explains why memory and visuospatial ability are typically spared. Psychomotor abilities, on the other hand, can be affected as the disease progresses and are not a defining spared domain in Pick’s disease.