Glaucoma is most commonly associated with which syndrome?

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Glaucoma in this context is most strongly linked to Sturge-Weber syndrome due to the eye and brain vascular malformations that define the condition. Sturge-Weber is a neurocutaneous disorder characterized by a facial port-wine stain in the distribution of the trigeminal nerve and leptomeningeal angiomas. Ocular involvement is common, and glaucoma can develop early because of abnormal development of the anterior chamber angle (trabecular outflow) and increased episcleral venous pressure from choroidal hemangiomas or venous malformations. This combination makes glaucoma a recognized and relatively frequent complication of Sturge-Weber, more so than in the other listed conditions. Prader-Willi/Angelman, tuberous sclerosis, and NF1 have their own hallmark features, but glaucoma is not a typical or defining association for them.