Angelman syndrome results from maternal imprinting on which chromosome?

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Multiple Choice

Angelman syndrome results from maternal imprinting on which chromosome?

Angelman syndrome is caused by loss of maternal expression of the UBE3A gene located on chromosome 15 (specifically 15q11-q13). In brain tissue, the paternal copy is silenced by imprinting, so when the maternal allele is deleted or inactivated, there is no functional UBE3A produced. This absence of UBE3A in neurons leads to the distinctive Angelman symptoms. The chromosome involved in this imprinting is chromosome 15, which distinguishes it from conditions linked to other chromosomes.

Angelman syndrome is caused by loss of maternal expression of the UBE3A gene located on chromosome 15 (specifically 15q11-q13). In brain tissue, the paternal copy is silenced by imprinting, so when the maternal allele is deleted or inactivated, there is no functional UBE3A produced. This absence of UBE3A in neurons leads to the distinctive Angelman symptoms. The chromosome involved in this imprinting is chromosome 15, which distinguishes it from conditions linked to other chromosomes.

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