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Multiple Choice

Angelman syndrome is best described by which statement?

Angelman syndrome presents with profound cognitive impairment, so describing it as severe intellectual disability best captures the overall clinical picture. In addition to this substantial intellectual disability, individuals often have little or no functional speech, frequent seizures, and motor problems such as ataxia. These features together make normal language development unlikely, seizures common (not absent), and ataxia present (not absent). Therefore, the statement that emphasizes severe intellectual disability aligns most closely with the syndrome’s characteristic profile.

Angelman syndrome presents with profound cognitive impairment, so describing it as severe intellectual disability best captures the overall clinical picture. In addition to this substantial intellectual disability, individuals often have little or no functional speech, frequent seizures, and motor problems such as ataxia. These features together make normal language development unlikely, seizures common (not absent), and ataxia present (not absent). Therefore, the statement that emphasizes severe intellectual disability aligns most closely with the syndrome’s characteristic profile.