Acoustic neuroma is a tumor of the eighth cranial nerve; bilateral tumors occur in autosomal dominant NF2 (neurofibromatosis type 2) due to a mutation on chromosome 22.

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Multiple Choice

Acoustic neuroma is a tumor of the eighth cranial nerve; bilateral tumors occur in autosomal dominant NF2 (neurofibromatosis type 2) due to a mutation on chromosome 22.

Bilateral vestibular schwannomas are a hallmark of neurofibromatosis type 2, caused by a mutation in the NF2 gene on chromosome 22 that encodes the tumor suppressor merlin. An acoustic neuroma is a vestibular schwannoma arising from Schwann cells of the eighth cranial nerve. The bilateral involvement of the eighth nerve in NF2 fits this tumor type perfectly, whereas the other options originate from different tissues and don’t specifically explain bilateral eighth nerve tumors.

Bilateral vestibular schwannomas are a hallmark of neurofibromatosis type 2, caused by a mutation in the NF2 gene on chromosome 22 that encodes the tumor suppressor merlin. An acoustic neuroma is a vestibular schwannoma arising from Schwann cells of the eighth cranial nerve. The bilateral involvement of the eighth nerve in NF2 fits this tumor type perfectly, whereas the other options originate from different tissues and don’t specifically explain bilateral eighth nerve tumors.

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